Naja: A Mobile Photoplethysmographic Analysis Tool for Early Detection of Preeclampsia and Hypertensive Disorders of Pregnancy

Organization: 
Massachusetts Institute of Technology
Organization Location: 
Cambridge, Massachusetts, USA

The MIT team has developed a new low-cost mobile tool that can be used with a mobile phone to help predict preeclampsia, which is the second leading cause of maternal mortality. The tool measures Pulse Wave Velocity (PWV), which is a direct measurement of vascular resistance and a leading manifestation of the endothelial dysfunction associated with preeclampsia. Compared to other traditional predictors of preeclampsia (BP, proteinuria, PO2Sat), the PWV measurement is fast, non-invasive, low-cost, and simple to administer. This project aims to measure PWV on 120 primipara women in a research hospital and compare the result against the gold standard aortic-femoral PWV velocity as assessed by a state-of-the-art echocardiogram equipment. In addition, the team will administer a clinical questionnaire (chest pain, vaginal bleeding) and also administer standard maternal laboratory tests and pulse oximetry. This study will provide a baseline for their screening algorithm which can be integrated into other existing models for prediction of preeclampsia for follow-on study and deployment.