Reducing Pre-Eclampsia Morbidity and Mortality in Resource-Limited Settings Through the Urine Congo Red Dot (CRD) Test

The Research Institute at Nationwide Childrens Hospital
Organization Location: 
Columbus, OH, USA

In limited-resource settings, morbidity and mortality from preeclampsia results from lack of/delayed diagnosis. Preeclampsia is a hypertensive proteinuric syndrome unique to human pregnancy. The problem is that neither hypertension nor proteinuria is sensitive or specific, especially in women with atypical presentations. We provided novel evidence that the urine of preeclamptic women is highly enriched in misfolded proteins. Based on this, we developed the Congo Red Dot (CRD) as a diagnostic and clinical prognostic tool for preeclampsia. This project takes advantage of our basic science finding (congophilia of preeclamptic urine), translating it in innovative manner toward development of low-cost paper-based diagnostics with potential to decrease maternal and fetal mortality worldwide.

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